Neuromodulation prime NRGs by six different domains: the amino-terminal region of the immunoglobulin-like domain, EGF-like domain, the juxtamembrane sequence of the transmembrane sequence and cytoplasmic domain. The NRGs existence of different forms of soluble and membrane chimeric. Most of the the NRGs First synthesis and membrane-bound precursor proN RGs proNRGs followed to produce soluble NRGs, and secretion of this form. NRGs may play a role in cell paracrine autocrine form.
ErbBs receptors ErbBs receptors membrane receptor, its structure consists of an extracellular binding site domain, a transmembrane domain, a tyrosine kinase domain and a C-terminal domain. The ErbBs receptor subtypes may form homo-or heterodimer, dimer functions and constitute a dimer receptor subtypes to stimulate the ligand and is activated in the intracellular signal transduction pathways related