The cardiovascular system NRG ErbB widely expressed in the cardiovascular system, but differences in their distribution in different tissues. Mainly distributed in the intima of developing ventricular NRG1mRNA, NRG2 mRNA is mainly distributed in the intima of developing atrial NDF (neu 1mR NA) expression in rat coronary microvascular endothelial cells in cardiac development and pathological hypertension are induced cardiac hypertrophy, myocardial cells and neighboring endothelial cells highly expressed NRGs. While rat embryonic development of the mid-ErbB2, ErbB3 and ErbB4 expression After ErbB3 expression was significantly down-regulated. ErbB2, ErbB4 distribution in atrial and ventricular myocardium, ErbB3 distributed in the mesenchymal cells in the endocardial cushion and Cordis ball. In human umbilical vein endothelial cells detected immune response kind of ErbB2, ErbB3 and ErbB4
Nervous system and other tissues in the nervous system of the neurons, astrocytes, oligodendrocytes, glial cells and Schwann cells receptor expression are ErbBs. Retinal neurons, breast cancer cells have NRGs distribution. Peripheral listen ganglion and vestibular ganglion ARIR highly expressed. NRG4 only expressed in mature cells of the pancreas, which showed low levels of expression in muscle cells.