Neuromodulation and Its ErbBs receptors in the cardiovascular system

Neuregulin (Neuregulins, NRGs), a member of the epidermal growth factor (EGF) family, a local role of polypeptide regulatory factors, plays an important role of the nervous system, such as NRGs promote the proliferation of Schwann cells and glial cells, differentiation adhesion, migration, and survival. Known NRGs, NRG1, NRG2, NRG3 and NRG4 four subtypes. The NRG1 Department with a gene encoding a product separation and purification and cloning in different laboratories, it is a different name, such as neu differentiation factor (of neu differentiationfactor NDF), human heregulin (HRG), glial growth factor (GGF) and acetylcholine the re ceptor inducing the activity (ARIA). In addition, three different genes encoding other types of neuregulin, respectively, NRG2, NRG3 and NRG4. Functional receptors for NRGs ErbBs, also known as epidermal growth factor receptor (EGFR), including four subtypes: ErbB1 of EGFR, ErbB2 of HER2 of neu of ErbB3 of HER3 and ErbB4 is HER4. NRGs and ErbBs receptor activation of the ErbB receptor tyrosine kinase induced by a wide range of biological effects, such as cell proliferation, differentiation, migration, adhesion, survival. Recent studies have shown that NRG of ErbB signaling pathway also plays an important role in the development process of the cardiovascular system, and to participate in the pathogenesis of cardiac hypertrophy.


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